Near future
Contact us
  • Home
  • Tech
  • Health
  • Environment
  • Architecture
  • energia
  • Transportation
  • Spazio
  • AI
  • concepts
  • Gadgets
  • Italy Next
  • H+
July 3 2022

Coronavirus / Russia-Ukraine

Near future

News to understand, anticipate, improve the future.

No Result
View All Result

News to understand, anticipate, improve the future.

Read in:  Chinese (Simplified)EnglishFrenchGermanItalianJapanesePortugueseRussianSpanish

There is a link between gut microbiome and stroke

The relationship between the intestinal microbiome and our diseases is now wide and clear: for vascular diseases and for stroke there are new, important discoveries.

Gianluca Ricciodi Gianluca Riccio
in Medicine
Share24Pin6Tweet15SendShare4ShareShare3
There is a link between gut microbiome and stroke
June 17 2021
⚪ Reads in 4 minutes
A A

New findings from Cleveland Clinic researchers show for the first time that the gut microbiome affects stroke severity and functional impairment after having one. The results, published on Cell Host & Microbe, lay the groundwork for potential new interventions to help treat or prevent stroke.

The research was conducted by Weifei Zhu e Stanley Hazen of the Lerner Research Institute at the Cleveland Clinic. The study is based on more than a decade of team-led research related to the role of the gut microbiome in cardiovascular health and disease. Among the findings obtained, noteworthy are those on the negative effects of TMAO (trimethylamine N-oxide), a by-product created by the interaction between intestinal bacteria and some nutrients abundant in red meat and other animal products.

Gut microbiome and stroke, a direct correlation

In this study, we found that dietary choline and TMAO produced larger stroke size and severity and poorer outcomes in animal models. Surprisingly, the simple transplantation of gut microbes capable of producing TMAO was enough to cause a profound change in stroke severity.

Stanley Hazen, chair of the Department of Cardiovascular and Metabolic Sciences and director of the Center for Microbiome & Human at the Cleveland Clinic
Stanley Hazen, co-author of the study on the relationship between gut microbiome and stroke

TMAO, messenger of death

Previously, Dr. Hazen and his team found that elevated TMAO levels can lead to the development of cardiovascular disease. In clinical studies involving thousands of patients, they have shown that blood levels of TMAO predict future risk of heart attack, ictus and death, results replicated around the world. Previous studies had instead shown a link between TMAO and increased risk of blood clotting.

Maybe you are also interested

Eliminating a protein could prevent heart attacks and strokes

NCyborg, wearable robot that helps rehabilitate stroke victims

BrainQ, artificial brainwaves against stroke

In Finland, a carpet in the forest improves the immune system of children

This new study builds on previous findings. And for the first time, it provides evidence that the gut microbiome (particularly through TMAO) can have a direct impact on stroke severity or post-stroke functional impairment.

Research on gut microbiome and stroke

The researchers compared brain damage in preclinical stroke models between those with high or low TMAO levels. Over time, those with higher TMAO levels had more extensive brain damage and a greater degree of motor and cognitive functional deficits. Dietary changes that alter TMAO levels, such as eating less red meat and eggs, also impacted stroke severity.

Function after a stroke is a major concern for patients. To understand whether choline and TMAO affect her, the team compared performance on various activities before and after a stroke, both in the short and long term. And he found that a gut microbial enzyme critical for TMAO production called CutC increased stroke severity and worsened outcomes..

Enzyme hunting

In the great "battlefield" represented by our gut microbiome, for Dr. Zhu, hitting this target (the CutC enzyme) can be a great idea. To do what? Improve stroke outcomes? No. To prevent it.

"When we genetically silenced the gut microbe gene that codes for CutC," says the doctor, "the severity of the stroke decreased significantly." But that is not all. "Ongoing research is exploring this therapeutic approach, as well as the potential of dietary interventions to help reduce TMAO levels and the risk of stroke itself."

intestinal microbiome
Photo by Scott Warman on Unsplash

A diet rich in meat (especially the red one elevates) the levels of TMAO. In a plant-based diet, protein sources help lower the TMAO.

Gut microbiome warned, half saved.

tags: ictusintestinemicrobiomemicrobiota
Previous post

Former government program leader: USA also evaluates non-terrestrial hypotheses

Next Post

The technological singularity will eventually render governments and societies useless. And U.S?

COLLABORATE

To submit articles, disclose the results of a research or scientific discoveries write to the editorial staff

    archive

    Have a look here:

    The air robot can help us out in space
    Robotica

    The air robot can help us out in space

    Easier to use, less complex, less expensive, lighter: "soft" air robots can be really useful for exploration ...

    Read More
    Jasper walks again thanks to the stem

    Jasper walks again thanks to the stem

    Simulation

    If we don't live in a simulation maybe it's worse

    POST FP 700X500 2022 04 20T173558.777

    A nano-drug precisely attacks chemotherapy-resistant cancer

    quantum computer

    Chinese quantum computer, 1 million times more powerful than Google

    The daily tomorrow

    Futuroprossimo.it provides news on the future of technology, science and innovation: if there is something that is about to arrive, here it has already arrived. FuturoProssimo is part of the network ForwardTo, studies and skills for future scenarios.

    Subscribe to our newsletter

    Environment
    Architecture
    Artificial intelligence
    Gadgets
    concepts
    Design

    Staff
    Archives
    Advertising
    Privacy Policy

    Medicine
    Spazio
    Robotica
    Work
    Transportation
    energia

    To contact the FuturoProssimo editorial team, write to [email protected]

    Chinese Version
    Édition Française
    Deutsche Ausgabe
    Japanese version
    English Edition
    Edição Portuguesa
    Русское издание
    Spanish edition

    This work is distributed under license Creative Commons Attribution 4.0 International.
    © 2021 Futuroprossimo

    No Result
    View All Result
    • Home
    • Tech
    • Health
    • Environment
    • Architecture
    • energia
    • Transportation
    • Spazio
    • AI
    • concepts
    • Gadgets
    • Italy Next
    • H+