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Medicine

We may have discovered how to reverse brain aging

A team has shown how deactivating a receptor can stop and reverse brain aging. An extraordinary step forward.

March 20 2021
Gianluca RiccioGianluca Riccio
⚪ 4 minutes
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The risk of death from a virus doubles roughly every nine years of life. And it's a nearly identical pattern to a host of other diseases. But why are older people vulnerable to so many different things?

One of the main hallmarks of the aging process in many mammals is inflammation. Not the local response we associate with a wound, but a kind of "inflammatory background noise", which gets louder as we live. This condition contributes to the development of atherosclerosis (accumulation of fat in the arteries), diabetes, hypertension, frailty, cancer, and brain and cognitive decline.

The discovery on brain aging

brain aging
Prostaglandin E2

A new study published in Nature has just revealed that microglia (a type of white blood cell found in the brain) is extremely vulnerable to changes in the levels of prostaglandin E2 (also known as PGE2), a major inflammatory molecule.

The team found that exposure to this molecule affects the ability of microglia and related cells to generate energy and carry out normal cellular processes.

Fortunately, the researchers found that these effects occurred only due to the interaction of PGE2 with a specific receptor on microglia. By interrupting it, they were able to normalize cellular energy production and reduce brain inflammation.

The article continues after the related links

A team of scientists read patients' minds to understand their pain

Discovered an aging "brake pedal"?

The result was brain improvement in older mice.

Huge prospects

The extraordinary discovery offers hope that the cognitive impairment associated withaging it is a transitory state that we can correct, and not the inevitable consequence of brain aging.

Levels of PGE2 increase as mammals age for several reasons. One of these is probably the growing number of cells in different tissues that enter a state called cellular senescence. This means they become dysfunctional and can cause tissue damage by releasing PGE2 and other inflammatory molecules.

The role of macrophages in brain aging

brain aging

The researchers also found that macrophages (another type of white blood cell linked to microglia) of people over the age of 65 produce far more PGE2 than those of young people.

It is not a small thing, indeed: exposure of these white blood cells to PGE2 suppresses the entire pattern of energy generation and cellular behavior.

The authors of this study succeeded in "turning off" a receptor responsible for the interaction between macrophages and PGE2. They treated white blood cells, grown in the laboratory, with drugs that activate or deactivate this receptor. It worked great, at least in a Petri dish.

What would happen in an intact body?

Brain aging
Photo by Glen Hooper on Unsplash

The researchers conducted a second phase of testing on mice. They took genetically modified animals in which the EP2 receptor had been removed and observed the brain aging process. They then tested their learning and memory by observing their ability to walk through a maze, and perform other memory tests.

Genetically modified older mice learned and remembered as well as young ones. These effects could be duplicated in normal elderly mice giving them one of the drugs that deactivate the EP2 receptor.

It may represent a new approach to the treatment of late age cognitive disorders.

Meanwhile eat fruit!

There is still some way to go before we can start using these drugs on humans, even though the prostaglandin systems are very similar.

But this study shows that reversing brain decline is possible. And it sheds light on a fascinating series of observations that link diet and cognition.

It has been known for some years that eating blueberries and other fruits and vegetables such as strawberries and spinach improves brain activity in rodents and older people.

They are foods rich in molecules such as resveratrol, fisetin and quercetin, which kill or block senescent cells.

Until something better comes along, therefore, go for it with fruit.

Tags: brainagingmice


GPT Chat Megaeasy!

Concrete guide for those approaching this artificial intelligence tool, also designed for the school world: many examples of applications, usage indications and ready-to-use instructions for training and interrogating Chat GPT.

To submit articles, disclose the results of a research or scientific discoveries write to the editorial staff

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