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May 28, 2022

Coronavirus / Russia-Ukraine

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UK government study: Covid-19, asymptomatic lose antibodies first

Bad news from studies commissioned by the British government: since the end of the lockdown, antibodies to the virus have dropped, especially in asymptomatic patients

Gianluca Ricciodi Gianluca Riccio
in Medicine
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covid-19, asymptomatics lose antibodies first
October 27, 2020
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According to one of the largest studies of its kind in Britain, reported Tuesday, the asymptomatic patients of coronavirus asymptomatic people seem to lose detectable antibodies earlier than patients who have experienced symptoms.

The results ofImperial College London they also suggest that the loss of antibodies, which is more rapid in asymptomatic patients, is slower in young people aged 18-24 than in people aged 75 and over. Altogether, samples from hundreds of thousands of people across England between mid-June and late September showed that the prevalence of viral antibodies it fell by over a quarter.

Research commissioned by the UK government

Research, commissioned by the UK government, indicates that people's immune response to COVID-19 declines over time as a result of infection, especially in asymptomatic people. James Bethell, an undersecretary of health, called it "A fundamental element that helps us understand the nature of COVID-19 antibodies over time".

Covid-19, asymptomatic people lose antibodies first
Transmission electron micrograph of a SARS-CoV-2 virus particle. 

But the scientists involved warned that much remains unknown about people's long-term antibody response to the virus.

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It is not clear what level of immunity the antibodies provide or how long this immunity lasts

Paul Elliott, Imperial's School of Public Health.

The results

The study involved 365.000 randomly selected adults who administered three rounds of finger-prick tests for coronavirus antibodies at home between June 20 and September 28. The results showed that the number of people with antibodies decreased by 26,5% over a period of about three months, particularly rapidly in the asymptomatic. Climbed up to a national level, it meant that the proportion of the British population with antibodies dropped from 6,0% to 4,4%, according to the study.

The decline in antibodies coincides with the summer easing of the national lockdown. However, the research found that the number of healthcare workers who tested positive for antibodies did not change over time, potentially reflecting repeated or greater initial exposure to the virus.

This very large study showed that the percentage of people with detectable antibodies is decreasing over time

Helen Ward, one of the lead authors of the study

We do not yet know if this will leave these people (especially asymptomatic ones) at risk of reinfection with COVID-19, but it is essential that everyone continues to follow the rules to reduce the risk, for themselves and for others.

tags: antibodiesCoronavirusCovid-19UK
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