Scientists have opened up the possibility of creating a cure for alcoholism after discovering a brain circuit that controls compulsive drinking.
The question of why some people develop alcohol problems more easily than others who seem immune to it has long alarmed (and a little confused) scientists across the planet.
Researchers are on the verge of solving the unresolved question: Will their discovery made in mice also apply to humans? Will it be effective, in other words, as the basis of a cure for alcoholism?
Much of the previous scientific literature has examined the effects of alcohol on the brain, but a team of scientists from the Salk Institute in California focused on demonstrating that certain brain circuits can increase the likelihood of some people becoming alcoholics.
“We have found for the first time a brain circuit that can accurately predict which mice will develop compulsive drinking weeks before the behavior begins.”, explained the researcher Kay tye.
This research bridges the gap between circuit analysis and alcohol addiction research and provides a first look at how representations of compulsive alcohol consumption develop over time within the brain.
The test in the laboratory
The team created a test to examine how susceptibility to alcohol consumption interacts with experience to create mice with alcohol problems (and in the future find a cure for alcoholism).
Through a series of tests, it was observed that mice could be sorted into three groups: light drinkers, heavy drinkers and compulsive drinkers. Unlike the first two groups, the compulsive drinkers showed insensitivity to negative changes, such as when scientists made alcohol bitter. Special imaging techniques were then used to map the cells and brain regions affected first by the urge to drink other drinks, then by the urge to drink alcohol.
The team paid particular attention to the activity of neurons in two regions involved in behavioral control and in response to adverse events. The finding was that the development of compulsive drinking was related to neural communication patterns between two brain regions and was a biomarker for predicting future compulsive drinking.
Optogenetics comes into play: a future treatment possibility for alcoholism
In a fascinating next step, the researchers they used light to control neural pathway activity. In a potential breakthrough discovery that could lead to a cure for alcoholism, they found they were able to increase or reduce compulsive drinking by activating or deactivating the brain circuitry.
