Suicide is one of the leading causes of death globally. Every year, in fact, over 700.000 people decide to put an end to their lives. In particular, it is the fourth cause of death for people aged between 15 and 29 years.
To try to prevent these tragic situations, a group of researchers decided to investigate genetics as a possible cause. The objective is to better understand the mechanisms underlying this phenomenon and, consequently, identify new strategies to prevent suicide.
A systematic review
Duke HealthIn partnership with Durham Veteran's Association, conducted a study of a large sample of US military veterans, analyzing the medical records of 633.778 individuals. During the investigation, it was found that 121.211 of these veterans had documented suicidal thoughts or actions in their medical records.
The control group used for this study was made up of individuals belonging to the same sample, but who did not have a documented history of self-harming behavior. This allowed us to evaluate the effect of exposure to military service on suicide propensity.
The results
The research conducted by Duke led to the complete genome-wide analysis of blood samples from all study participants. The analysis highlighted several genes that were more frequently present among those who had documented suicidal thoughts or actions. This association was independent of the participants' background. In essence, there are 4 genes, four "horses of suicide" related to this risk and also associated with psychiatric conditions such as depression, anxiety and psychosis.
The four geniuses “knights of suicide”
- ESR1 it is a gene that controls the body's response to estrogen. Recent studies have shown that a low level of this gene can increase the risk of suffering from disorders such as post-traumatic stress and depression, both risk factors for suicide.
- DRD2 controls the body's response to dopamine, a brain chemical that makes us feel happy and motivated. A low level of this gene can increase the risk of suffering from suicide, schizophrenia, mood disorders, ADHD and addictions.
- DCC deals with communication between brain cells. Recent studies have shown that a high level of this gene can increase the risk of suffering from various psychiatric conditions and dying by suicide.
- TRAF3 instead it controls inflammation of the brain. Recent studies have shown that a high level of this gene can increase the risk of antisocial behavior, substance dependence and ADHD, and may be a risk factor for bipolar disorder and suicide.
Towards genetic treatments against suicide?
Identifying these four key genes could lead to new treatments for psychiatric conditions that often lead to a greater risk of suicide. An important step to potentially save hundreds of thousands of lives every year. It is suggestive to imagine a future in which advanced genetics can even "stop" the possibility of suicide in an embryo, before a child even comes into the world.
Ethical doubts arise in any case. Knowing that the predisposition to suicide or depression has a genetic basis could provide a set of important information, which in the wrong hands would very easily allow people with these difficulties to be manipulated. Perhaps, however, the risk is worth it: in the vast majority of cases, in fact, suicide is anything but a "political" or identity-related gesture that represents individual freedom.
