A new large-scale study is marking a turning point in the vast field of life extension research. By testing the combined effect of four therapies on 1000 mice, a team of scientists is opening the door to previously unimaginable possibilities. The target? Demonstrating that the combination of these therapies can not only extend life but double it, offering a new perspective on the fight against aging.
Challenges and discoveries
Longevity research has made great strides in recent decades, with numerous studies identifying potential avenues to slow the aging process. This latest study, conducted by LEV Foundation, aims to explore the combined effect of four specific therapies. Four "knights" against the damage of old age.
What am I talking about? Ablation of senescent cells through Navitoclax conjugated to galactose (Nav-Gal), administration of rapamycin in food, enhanced expression of telomerase through TERT gene therapy and hematopoietic stem cell transplantation.
Preliminary observations
Although definitive results are still far away, preliminary data suggest that the combined approach could be promising. Aubrey de Gray, a renowned biogerontologist, shared his observations on emerging trends, highlighting how rapamycin and TERT gene therapy appear to offer the greatest benefits, both individually and in combination.
For example, rapamycin, a macrolide drug, has been shown to extend life in several model organisms, including mice, by delaying many age-related diseases.
Combined anti-aging therapies: next steps
I remind myself often, it is always worth it: longevity research is not just about extending life but also about improving the quality of life in later years. The results of this study could open new avenues in preventing age-related diseases and promoting a longer, healthier life. The prospect of doubling the remaining lifespan of a middle-aged mouse represents a potentially revolutionary breakthrough in longevity research.
While waiting for complete results and detailed analyzes (we are one year away from the conclusions), I daydream: we could be on the verge of unlocking the secrets of aging, paving the way for a future in which we live longer and healthier. it is only possible but achievable.
