A recent study brings a breath of hope for those suffering from spinal cord injuries. By developing drug-loaded nanoparticles, researchers have discovered a promising method for reducing harmful inflammation following spinal injury, dramatically improving motor function in animal models.
It is an innovative and entirely Italian approach, which can mark a turning point in the treatment of spinal injuries, opening up new therapeutic possibilities.
The challenge of post-spinal injury inflammation
Spinal cord injuries lead to devastating consequences. Devastating. Not only due to the immediate impact, but also due to the subsequent inflammation which can significantly aggravate the damage.
Research has shown that, in the days following a spinal injury, the microglial cells they activate and proliferate. This contributes to secondary damage through the production of pro-inflammatory cytokines. A process that can lead to paraplegia or quadriplegia, conditions that may not be apparent initially.
A nanotechnological solution
Addressing the challenge of inflammation requires targeted therapies. Therapies that can selectively reach the cells involved without affecting the rest of the organism. Scientists at the Mario Negri Pharmacological Research Institute, in collaboration with the Polytechnic University of Milan, have developed nanoparticles based on nanogels capable of targeting these cells.
The nanoparticles release an active compound that reduces inflammation.
“Load” with Rolipram, an inhibitor of phosphodiesterase 4 (PDE4) – a regulator of the production of pro-inflammatory cytokines – these nanoparticles represent a significant advance in the treatment of spinal injuries. The studies, published in Advanced Materials, I am at your disposal here.
Proven effectiveness and new hopes
Tests on animal models have shown that treatment with these nanoparticles works really well. When administered immediately after injury, it significantly reduced inflammation.
Now we need to proceed with further research. There is a need, in particular, to translate these discoveries into safe and effective therapies for humans. The possibility of partially restoring motor function following spinal cord injury is no longer a mirage now.
It is a realistic goal towards which science is advancing with decisive steps.
