By targeting a different part of the viral protein, a new type of vaccine could protect against the flu in one shot, with no more annual boosters.
Each year the flu vaccine must be redesigned to account for new mutations. Researchers at MIT and Harvard are now hoping to find a better strategy.
The problem with the flu shot
When the flu vaccine induces the production of antibodies against the flu virus, these antibodies tend to target a viral protein segment that is particularly prone to mutation. If the antibodies could bind to the "stem" of the stable protein instead of its changing "head", they could protect against any flu strain, and people wouldn't need to receive new doses year after year.
The creation of a universal flu vaccine
A research team led by Arup K. Chakraborty of MIT and Daniel Lingwood of the Ragon Institute, used computational models to explore why the immune system focuses on the head of the protein. A systematic review he also explored the possibility of "training" the immune system to focus on the "stem" of the protein.
The result of their work is a vaccine made of nanoparticles coated with flu proteins that do just that.
In studies of mice with humanized immune systems, researchers have shown that their flu vaccine elicits an antibody response to the protein stem, increasing the chances that they could finally ending the "arms race" between vaccine designers and the ever-evolving virus.
Once and forever
“The reason we're excited about this job,” he says Chakraborty, "Is that it is a small step towards developing a flu vaccine that is taken only once or at most a few times, and whose resulting antibody response protects both from various flu and pandemic strains."
It even sounds too good to be true. A Vaccine such would be a step forward for the human species equal to that of the colonization of the cosmos, but a terrible blow to the economy of those who annually produce billions of doses of flu vaccine.
For this reason, although I have the utmost confidence in science and respect for the pharmaceutical industry, if it were up to me I would “militarize” these researches and have them continue on a state basis, to secure the results.