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Medicine

ECMO medicine, the miracle machine: death goes on standby

ECMO is a machine capable of saving or making people who are already dead survive even for months. A miracle that however raises enormous ethical doubts

July 12 2019
Gianluca RiccioGianluca Riccio
⚪ 10 minutes
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The latest (increasingly used) modern medical miracle machine is called ECMO and can literally save people on the brink of death. I'm talking about people with no functioning lungs, trapped underwater, or with a steady heart.

What is ECMO medicine, the machine that puts death on standby? First of all, ecmo is not a convenient tool: for every person saved by ECMO (the acronym stands for Extracorporeal Membrane Oxygenation, in Italian Extracorporeal Membrane Oxygenation) there is one that dies despite its use.

ECMO is the most aggressive life support procedure, very expensive and demanding for the patients themselves: almost a trick against death. Indeed, to be honest: it is the exact opposite of "death machines": in a certain sense it "tortures" the body to keep it alive. It pumps the blood out of the body, oxygenates it and puts it back inside, keeping a person alive for days, weeks, months even with a stopped heart or lung.

ECMO medicine how it works - death on standby
A simplified diagram of the functioning of ECMO cardiac surgery, the extracorporeal breathing system

This machine created "a new paradigm," according to Dr. Kenneth Prager, director of clinical ethics. "You can have a patient with a heart that stops beating, but still keep him alive and awake thanks to the ecmo. You can put death on standby."

Created to give life support to newborns, the ECMO is increasingly used also on adults. In the USA procedures have tripled in the last 4 years according to the Federal Health Research Agency.

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ECMO is not designed as a solution to a problem (it is not) but as a bridge that saves the patient until recovery, recovery or transplant. But when patients are too sick, ECMO becomes just a very expensive (and cruel, in some ways) limbo that leaves them awake and conscious but with zero chance of survival without the machine. Doctors and family members only need to determine when to unplug and watch the patient end.

ECMO machinery: very high cost

Really. The average ecmo cost is around 600.000 euros per week. The heart-to-machine-price ratio is prohibitive. In a recent case, a hospital asked 4.5 million euros for less than 60 days of stay for a 19-year-old with a very serious respiratory syndrome, who remained in a coma awaiting a lung transplant that did not arrive.

The more ecmo spreads, experts say, the greater the need to educate staff on whether or not to use it and how to use it correctly.

ECMO logo

Four ECMO stories

The incredible events (this is the tenor of all cases involving ECMO) of four patients can make us understand the possibilities and complexity of this technology.

Seven hours

The doctor Jessica Zitter she was on duty at the Oakland hospital in California when she was alerted by a red code. A 60-year-old patient with severe ventricular fibrillation that made him literally contort with convulsions.

The staff performed a heart massage and an emergency tracheostomy to aid breathing. It didn't work. They applied the defibrillator and released two shocks. It didn't work. His oxygen levels were on the ground. Someone was already arranging for the post-death cleaning of the "corpse". The team decided to try the use of ecmo, a real "blood recovery machine", requesting intervention from the University of San Francisco which sent the machine as soon as possible.

Upon ECMO's arrival, Dr. Zitter could not help but watch the procedure helplessly. A large tube was literally inserted into the patient's femoral artery, another into the femoral vein. When the blood began to flow out of the body to pass through the respiratory echo, the patient was almost black from deoxygenation. Just a minute later his complexion was back to normal.

Zitter, who has written essays on excess technology in an attempt to put death on standby and prolong survival, gave no hope anyway: the patient was already dead, she just didn't know. He had waited seven hours, a full seven hours with his heart still waiting for the surgery.

Imagine the shock of seeing the patient recovered and ready to be discharged.

"It was a crazy, crazy, crazy borderline case with a crazy, crazy, crazy reaction," is keen to specify. And he's right.

When patients undergo cardiac ECMO and respiratory ECMO at the same time, only one in three leaves the hospital alive. Higher rates are found in case of respiratory-type interventions - only in the lungs (59%) or cardiac surgery - only in the heart (42%).

The failure of Christmas

A more common case is like the one that happened to Dr. Haider Warraich of Duke University during his internship in cardiac surgery.

Warraich was called to the waiting room where a XNUMX-year-old expecting a lung transplant had collapsed to the ground after a heart attack. The man, white-haired and bearded, played Santa Claus in a play when a respiratory crisis necessitated a lung transplant.

His heart, short of oxygen, started racing and the defibrillator didn't solve the problem either. Here, too, the practice of post-death cleaning was started and then stopped. Motivated to save not only the man, but also the new lungs that would otherwise have been lost, the doctors asked for ECMO therapy.

Once connected to the machine, the man's body was stabilized and he was given an angioplasty. No way. The kidneys were also in a critical phase, and nothing could restore a chance of survival. What was he like? Oh yes. Death on standby. After more than a month of limbo, the plug was pulled.

"In this case," says Warraich, "ECMO seemed appropriate. But doctors need more experience to understand when it is really useful and when it sets up a form of persistence. Of course it is not easy, when a person is dying in front of your eyes, to decide clearly."

The technology, developed in the 70s, did not have encouraging results for adults until 2009, when the first positive results in the UK on patients with severe respiratory problems made her interesting.

The "desperate" treatment of swine fever later justifies (and widespread) the use of ECMO among adults. The mean age of the first patients was 51 years, 10% over 65.

An intolerable choice

When a patient is on ECMO, the decision on when to stop using it is always difficult and causes divisions in the medical staff, says Dr. Robert Truog, director of the Center for Bioethics at Harvard Medical School.

In one case illustrated in Lancet magazine, a 17-year-old arrived in the emergency room at Boston Children's Hospital, where Truog works internally. The boy, who had already undergone a lung transplant due to cystic fibrosis, was no longer breathing. The only way out was a new pair of lungs: he was placed in the ECMO to keep him alive pending a new transplant.

The boy was conscious, he wrote to friends, did some remote work, received visits from relatives. After two months of "artificial" life, yet another blow: he was diagnosed with inoperable cancer, which made him no longer fit to receive new lungs.

The doctors at this point were divided on what to do, says Truog. Some wanted to immediately disconnect the respiratory ECMO to make room for other patients who still had a chance. Others refused, knowing full well that detachment from the machines would lead to immediate death a patient who for the moment had a good quality of life.

A real moral dilemma.

For the relatives it was intolerable to choose a moment to turn off the ECMO medicine when their relative was still alive and conscious, knowing that he would die instantly.

In the end the doctors chose a solution shared with the relatives: they did not replace the membrane oxygenator of the ECMO, a piece that had to be replaced every two weeks to avoid blood clots. After about ten days, the machine slowly lost effectiveness and the patient lost consciousness, dying shortly after.

The solution once again allowed death to be put on standby. To be precise, it allowed to choose an unspecified time of death. But it was still atrocious.

The long goodbye

ECMO medicine - Philip Ayub - death on standby
Philip Ayub with his boys in a photo of the shelter.

Karen Ayoub had never heard of ECMO until her husband was forced to use it.

Philip Ayoub, 58, was a man of great charisma, a lover of the family: the couple had twins and lived in Greenwich, Connecticut. A congenital and family heart problem forced him to his first bypass at the age of 30, with a second surgery just 13 years later.

In December 2017 he was operated on for a third bypass but things went wrong: his heart was weaker than expected. He lost consciousness and was rushed to the Columbia University Medical Center, which was outfitted with a medical ECMO.

Karen Ayoub said that putting her husband in the ECMO machine was an easy decision: "I thought he deserved every chance of survival." But she didn't know how she would react.

When her husband regained consciousness he said: "why am I here?". She stayed in the ICU for two months: one tube to feed, one to breathe, ECMO medicine, and dialysis.

ECMO, it was not in vain

He began to suffer from post-traumatic stress disorder, night panic and other physical and psychological side effects. Meanwhile, all the treatment options explored proved impractical, and it soon became clear that Philip's procured agony would be useless.

Yet Karen considers it a beautiful gift to have been able to spend more time with her husband, albeit little. And Philip did not pass a single day, even in great suffering, without repeating constantly "I will always love you, I will always be with you" to his wife and children.

When Karen told Philip that she had decided to stop life support, Philip was not afraid. He told her "I can't wait to know what's next". They sedated him, embraced and watched until the end.

ECMO a "useless" cure

While the Ayoub family faced fate with heartwarming courage, other families are by no means ready to let a loved one go.

Some patients in ECMO medicine have severe and irreversible brain damage. They are not in a position to participate in a decision about their life, and in fact have no hope of getting out of the hospital alive.

For them, several palliative care experts write, ECMO represents "the most extreme form of medical uselessness". For them, doctors should have the authority to terminate life support in cases like these, even if against the opinion of families. Ok death on standby, but there is a limit to everything.

The law is involved, however. "In the US there have been states like Idaho, Oklahoma and New York that do not allow doctors to shut down ECMO without the consent of patients or family members," says Thaddeus Mason Pope, director of the Health Law Institute at Mitchell Hamline School of Law in St. Paul, Minnesota. In other states such as California, Texas, and Virginia, doctors can proceed without consent.

Ethical limits of the ECMO

Doctor Robert Bartlett, a true pioneer in the field of ECMO and professor emeritus at the University of Michigan, says that when ECMO becomes a hopeless limbo, the family must be alerted and the time has come. "It's painful and rude to give the family responsibility for a choice that doesn't exist," He says.

Several hospitals are preparing to take advantage of these short waiting periods before a detachment to help families deal with it and accept it.

Because if there is a moral behind the promises and limits of a "miracle machine" like ECMO medicine, it is that miracles do not exist. Any advanced device for health of the future it will always carry a gigantic load of expectations and hope. The challenge is to temper this hope with reality, so that it is clear that every innovation presents new answers, but also new ethical questions that make us grow technologically, emotionally and spiritually.

ECMO teaches us that just because we can do something doesn't mean we have to do it or that it's the right thing to do. And that putting death on standby sometimes is of little use, if on standby in addition to death there is also life.




GPT Chat Megaeasy!

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To submit articles, disclose the results of a research or scientific discoveries write to the editorial staff

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