The question I have asked myself and many others more often over the last 10 years is: with all this technology, artificial intelligence, autonomous cars, drones, how come we haven't defeated cancer yet?
Before telling you about Alpha DaRT I would like to try to address the question above. Well, there are obviously many answers. The first is that there is no such thing as a “cancer grinder”. We give it one name, but each cancer is different and probably needs a different type of treatment.
The second thing is that in many cases it has actually already been defeated, at least medically. There are endless cutting-edge treatments being implemented even in these weeks, and endless additional cutting-edge research projects underway.
There are always new discoveries, many of which await FDA approval. If there's one thing that many of these treatments and cures have in common, though, it's that they're developed in a small country that's located in a very, very complex geopolitical area. When it comes to cancer research, Israel is at the forefront.
Finally, the last time I wrote about cutting-edge treatments for cancer, I was contacted by fellow journalists who are also doctors. They rightly pointed out to me that when I write these articles there is always a caveat: the last thing oncologists need is for their patients to think there is some magic solution here and show up to their appointments with a printed article .
In fact, the last thing a cancer patient needs is false hope.
This is why my disclaimer is that this company is undergoing a clinical trial and, if everything goes according to plan, the tumors could be much more manageable and treatable than they are today, but many things must happen before arriving. there.
La Alpha Tau Medical has developed a new cancer treatment that destroys aggressive tumors while sparing healthy tissues to minimize side effects.
This treatment is called Alpha DaRT and uses, for the first time, the alpha radiation for the treatment of solid cancer.
Cancer treatment involves a lot of collateral damage to the surrounding area and to the body as a whole. We are not designed to undergo these treatments.
Cancer is the second leading cause of death in the world, and has been steadily increasing over the last 50 years. The causes include longer life expectancy, lifestyles that promote carcinogenesis (e.g. smoking and high-fat diets) and negative environmental influences such as pollution and electromagnetic radiation.
Today there are many cancer treatment options available, with different levels of efficacy and safety.
However, when the tumor is inoperable or there are multiple tumors, good treatment options are limited and the medical community has long sought a very powerful cancer therapy that spares healthy tissues.
Alpha DART (Diffusing Alpha-emitters Radiation Treatment) is the first technology to provide highly localized and effective treatment of solid tumors using alpha radiation.
Alpha particles are known for their high ability to destroy cancer cells. However, alpha particles have an extremely short path length in tissue, meaning they cannot reach the entire volume of a tumor and therefore, until recently, could not be used as a treatment for solid tumors.
How Alpha DaRT works
ALPHA DaRT technology allows alpha particles to be spread across entire tumors using the radioactive decay of an isotope called radium-224. The treatment is delivered by inserting small Alpha DaRT “grafts” into the tumor that contain radium-224 atoms embedded in their surface.
In the decay process, radium-224 releases atoms that emit alpha. These atoms spread over a radius of several millimeters, providing a high dose of alpha radiation along the way.
The advantage of alpha radiation that characterizes Alpha DaRT is its very high “cancer-killing potential” combined with its short range of side effects. These unique features limit collateral damage to surrounding healthy tissue while effectively destroying the tumor.
This is a technology specification document.
Other radiation therapies using beta, X-rays, and gamma radiation have longer courses that cause more collateral tissue damage and must be dosed at higher levels to achieve the same local “carcinogenic effect.”
Alpha DaRT technology was invented by two professors from Tel Aviv University: physicist Prof. Itzhak Kelson and immunology Prof. Yona Keisari. The CEO Uzi Sofer founded Alpha Tau in 2016 with the goal of making this very promising technology available to millions of patients around the world.
In a recent study, Alpha DaRT was shown to be effective in humans for local, radiation-resistant, recurrent aggressive cancers of the skin, head and neck.
It also demonstrated a very high level of safety for patients, without causing systemic toxicity and only mild short-term local toxicity.
Here is the list of publications related to Alpha DaRT technology.
Treatment led to tumor reduction in 100% of cases and produced a complete response (total tumor destruction) in over 78% of cases! It seems almost too good to be true.
The study results also showed that Alpha DaRT possesses many attributes that can contribute to an overall positive patient treatment experience. These include:
- A single, minimally invasive outpatient procedure for inserting the Alpha DaRT device, without the need for special shielding or an operating room;
- A total duration of the treatment of only two weeks, in which the patient can be at home and live his life normally;
- Measured tumor reduction in a few days.
In addition to its value as a single tumor treatment, Alpha DaRT has shown great potential in preclinical studies for the treatment of metastatic cancer, when combined with immunotherapy.
This is the company's contact page to request possible participation in clinical trials.
Metastases are the primary mechanism of death from cancer, so any treatment that can reduce the extent of metastatic growth will prolong patient survival and hopefully reduce some of the suffering and terror that patients feel after a metastatic diagnosis.
Many major cancer centers around the world are currently studying Alpha DaRT for various types of cancer, including breast and pancreas. Tests take place in locations including Israel, Canada, Japan, Russia, Italy and the United States at prestigious institutions such as the Memorial Sloan Kettering Cancer Center in New York and the Montreal University Hospital Center (CHUM).
Alpha Tau is growing rapidly, from fewer than 10 employees in 2016 to over 40 in 2020. To support the growing demand for Alpha DaRT, the company is building global manufacturing facilities in Massachusetts, Israel and Japan.
The main investors in Alpha Tau's growth include Shavit Capital, OurCrowd, Medison Ventures, Alan Patricof and Sir Ronald Cohen.
Alpha DaRT has the potential to bring hope to cancer patients worldwide: the results are becoming more and more remarkable.
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