No Result
View All Result
Thursday, January 28, 2021
Chinese (Simplified)EnglishFrenchGermanItalianJapanesePortugueseRussianSpanish
  • |
  • Tech
  • Medicine
  • Society
  • Environment
  • Spazio
  • Transportation
  • Weather
  • concepts
  • H+
No Result
View All Result

Covid-19 Updates »

November 9, 2019
in Medicine

The drug that blocks glutamine slows down the tumor

Chinese (Simplified)EnglishFrenchGermanItalianJapanesePortugueseRussianSpanish

Collaborate!

We are open to visions about the future. Submit an article, disclose the results of a search or scientific discoveries, shows points of view on a theme, tells about a change.

CONTACT US
slow down the tumor

Jonathan Powell and Barbara Slusher of Johns Hopkins Medicine with a sample of the compound

Share42Pin2Tweet7SendShare2
tags: cancerglutamineMetabolismtumor

By hitting glutamine, the team was able to slow down the tumor and alter the metabolism of the tumor microenvironment, "awakening" the immune system.

Gianluca Ricciodi Gianluca Riccio
3 minutes of reading

The last

Trivalent gel: contraceptive, antiviral and knows how to increase libido

Kubota, glasses that eliminate myopia like a laser

Why Covid will not kill cities

Recycling, here are bottles and cardboard jars to “assemble” like IKEA furniture

Ovarian function recovered in infertile mammals without gonadotropins

Read also:

The UK towards driverless car lanes

The UK towards driverless car lanes

Stop trees felled: MIT studies how to create wood in the laboratory

Stop trees felled: MIT studies how to create wood in the laboratory

Bill Gates and the Harvard Climate Project. Who said "Chemtrails"?

Bill Gates and the Harvard Climate Project. Who said "Chemtrails"?

Biocollar, the collar that lets you know the needs of your plants

Biocollar, the collar that lets you know the needs of your plants

The submarine of the future? It will swim like a robot squid

The submarine of the future? It will swim like a robot squid

Regenerating therapy, we are now one step away: there are just 5 years left.

Regenerating therapy, we are now one step away: there are just 5 years left.

Hi-tech capsules for homeless people: in Germany they test the Ulmer Nest

Hi-tech capsules for homeless people: in Germany they test the Ulmer Nest

Squall Tower, the turbine skyscraper that rotates with the wind

Squall Tower, the turbine skyscraper that rotates with the wind

person holding black iPhone displaying stock exchange

Some great wallets starting in 2020!

triggo electric quadricycle

Triggo EV, electric quadricycle that pulls on its wheels to park

Home hydrogen storage system: a little "wow!" and a little "ah."

Home hydrogen storage system: a little "wow!" and a little "ah."

A bacteria-based self-healing paste can regenerate historic buildings

A bacteria-based self-healing paste can regenerate historic buildings

A research team from the Johns Hopkins Cancer Center has developed a critically important compound. It blocks the metabolism of glutamine, an amino acid involved in digestive processes, slows tumor growth, and alters the tumor microenvironment. Not only that: it promotes the production of resistant and highly active anticancer T cells.

"In theory, this tumor-slowing compound can be used in various types of neoplasia," says Jonathan Powell, at the head of the study published online on 7 November on Science.

By targeting glutamine metabolism, we were not only able to inhibit tumor growth and change the tumor microenvironment, but also to alter T-cells in a way that greatly improved cancer immunotherapy.

Jonathan Powell, associate director of Bloomberg ~ Kimmel Institute for Cancer Immunotherapy at Johns Hopkins Kimmel Cancer Center

Although glutamine metabolism is a component of all cells in the body, the DON drug selectively targets cancer cells because they are the "hungriest" for glutamine, Powell said. 

Maybe you are also interested

OncoHost, artificial intelligence that can “design” oncological therapies

Vaccine against cancer: PD1-Vaxx, ok animal tests: now human ones

Vaccine against melanoma: it is now twice as powerful

New study: Glutamine crucial for regenerating muscles from injury and aging

"What is emerging in metabolic therapy (this is why it is so important) is that a treatment like ours becomes selective because it preferably affects the cells that have the greatest demand."

Powell and colleagues tested the drug, nicknamed DON JHU083, in laboratory sessions on mice with colon cancer, lymphoma and melanoma.

JHU083: the results of an aspiring cancer killer.

"At the beginning our thought was that if we had addressed the metabolism of the tumor we would have achieved two objectives: slow down tumor growth and alter the tumor microenvironment", he claims Powell. 

The tumor microenvironment (i.e. the cells, blood vessels and nutrients found in tissues adjacent to tumors) is very hostile to the immune response. It is usually acidic, hypoxic and nutrient-depleted. Basically it is an "immune system" that defends cancer ... from the cure.

In mice, treatment with JHU083 led to a significant reduction in tumor growth and improved survival in many types of cancer. The metabolism of cancer cells is literally derailed. Its effects on the tumor microenvironment are devastating. In some mice, treatment with JHU083 alone led to lasting cures. 

Easier to heal, more difficult to get sick again

These cures were facilitated because metabolic therapy triggered the natural antitumor immune response. When the researchers replenished these cancer-free mice with new tumors, they found that nearly all of them rejected the new tumor. This suggests that the JHU083 treatment had produced a powerful immune memory to recognize and attack the new tumor.

The group also showed that treating the tumors with JHU083 improved the efficacy of adoptive cell therapy. It is a type of immunotherapy in which immune T cells are collected and grown in large numbers in the laboratory before being administered to patients to increase the immune response against cancer. 

Potentially, tumors that develop metabolic pathways to avoid the impacts of JHU083 could find themselves in a "dead end," Powell said. "By adding an additional metabolic antagonist, you could potentially eliminate even resistant tumors."

Comment this post on all the social networks where Futuroprossimo.it is present ( Facebook, Instagram, Twitter, Telegram, Linkedin, Vkontakte, Flipboard )

The future of:

Artificial intelligence

Engineers use AI to convert ancient maps into satellite images

transhumanism

Nectome wants to preserve (and digitize) your brain

Super Gadgets

CLIP, portable electric motor that turns every bike into an ebike

Design

Therapeutic tools like Balisa help patients see healing

Most read of the week

  • Australia, found the way to cure Crohn's disease

    Australia, found the way to cure Crohn's disease

    7387 shares
    Share 6170 Tweet 507
  • Squall Tower, the turbine skyscraper that rotates with the wind

    91 shares
    Share 36 Tweet 23
  • Triggo EV, electric quadricycle that pulls on its wheels to park

    87 shares
    Share 35 Tweet 22

The last

Investing in Bitcoin - A Complete Guide to Teach Beginners!

Next war after Covid: removing CO2 and saving the climate

Micromobility, Robotaxi, Smart City: 3 predictions for 2021

Covid variants: can they bypass vaccines? The first answers arrive

Fast battery charging at 100%, Storedot has one that takes 5 minutes

Next article
Pharmaceutical company announces: we have the cure for HIV and AIDS

Pharmaceutical company announces: we have the cure for HIV and AIDS

Futuroprossimo.it is an Italian resource of futurology opened since 2006: every day news about the near future. Scientific discoveries, medical research, prototypes, concepts and predictions about the future for free.

Tag

Environment Architecture Communication concepts Advice Energy Events Gadgets The future of yesterday The newspaper of tomorrow Medicine Military Weather Robotica Society Spazio Technology transhumanism Transportation Video

Categories

The author

Gianluca Riccio, copywriter and journalist - Born in 1975, he is the creative director of an advertising agency, he is affiliated with the Italian Institute for the Future, World Future Society and H +, Network of Italian Transhumanists.

Collaborate! Are you interested in writing a post on Futuroprossimo? Click here for contacts.

Home / Author / IDEA / archive / Promo on FP

© 2020 Futuroprossimo - Tailored by Be Here

© 2020 Futuroprossimo - Tailored by Be Here

  • Home
  • Contact us
  • archive
  • Technology
  • Medicine
  • Transportation
  • Weather
  • Society
  • Environment
  • transhumanism

© 2019 Futuroprossimo - Tailored by To be here

This site uses cookies. By continuing to read it, you consent to their use.