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Medicine

Asthma, key mechanism behind airway thickening uncovered

The crucial results pave the way for a path that could finally fight the very origin of chronic asthma instead of just working on the symptoms.

December 12 2022
Gianluca RiccioGianluca Riccio
⚪ 3 minutes
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The possibility of a long-term treatment for severe asthma is approaching. The credit goes to the results obtained (after more than 10 years of work) by an institute of immunology in the USA. The focus of the studies is a way to block the thickening of muscle tissue in the airways in patients.

How does this finding relate to chronic asthma?

In patients with chronic asthma, tissue remodeling occurs: the smooth muscle of the airways produces a thickening that progressively worsens the patient's breathing problems.

"Current treatments for asthma, even the most innovative ones, mainly serve to suppress symptoms and reduce allergic inflammation,” he explains Haruka Miki, a researcher who worked on the study. "There is still no treatment to eliminate asthma. Especially in its severe form, even when the inflammation is suppressed, the underlying airway hyperresponsiveness and airway remodeling remain."

The article continues after the related links

Childhood allergies? Let's prevent them with "farm dust"

chronic asthma
Current treatments for chronic asthma only work on symptoms or inflammation.

Ten years of work

in 2011 the discovery that started it all. Researchers at the La Jolla Institute for Immunology revealed that a certain immune molecule (called LIGHT) is key to the thickening of the airways in asthma patients. This protein, called LIGHT, is produced by T cells in large quantities when the body comes into contact with an allergen.

The La Jolla team has been looking for the mechanism of involvement of the LIGHT protein ever since, and now they seem to have found it. In the new study, published in the Journal of Allergy and Clinical Immunology (I link it here), the researchers examined two key receptors expressed on airway smooth muscle cells.

One of these two receptors (LTβR) is vital for tissue remodeling. The finding is that LIGHT molecules that bind to LTβR receptors trigger the airway thickening observed in chronic asthma.

"When those cells in the lungs can't express LTβR, all the hallmarks of the response associated with severe asthma disappear or are very limited." According to the study's senior author, Matthew Croft.

The prospects for the fight against asthma

While this finding doesn't immediately mean we should expect a new treatment for severe asthma in the next year (or the next), it does show promise for future therapies that address the structural airway problems associated with chronic conditions like this.

If a treatment could be found that either prevents LIGHT proteins from binding to LTβR or reduces LTβR volumes in airway cells, it could prevent one of the major physiological features of chronic asthma. The La Jolla team is currently collaborating with a pharmaceutical company to explore the possibility of turning these findings into a drug treatment.

In summary, this finding offers hope that one day we will be able to effectively treat and even prevent airway remodeling in asthmatic patients. I look forward to reporting on further progress in this area.

Tags: asthma


GPT Chat Megaeasy!

Concrete guide for those approaching this artificial intelligence tool, also designed for the school world: many examples of applications, usage indications and ready-to-use instructions for training and interrogating Chat GPT.

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