Near future
No Result
View All Result
27 September 2023
  • Home
  • Tech
  • Health
  • Environment
  • Energy
  • Transports
  • Spazio
  • AI
  • concepts
  • H+
Understand, anticipate, improve the future.
CES2023 / Coronavirus / Russia-Ukraine
Near future
  • Home
  • Tech
  • Health
  • Environment
  • Energy
  • Transports
  • Spazio
  • AI
  • concepts
  • H+

Understand, anticipate, improve the future.

No Result
View All Result
Medicine

We know how to repair and regenerate heart muscle cells

The discovery of a mechanism to repair the heart muscle has the potential to revolutionize heart treatments and cures

June 24 2022
Daniel FerrignoDaniel Ferrigno
⚪ 3 minutes
Share4Pin3Tweet2SendShare1ShareShare
repair heart muscle

READ IN:

Researchers from the University of Houston, Texas, unveiled a new technology that not only repairs heart muscle cells in mice, but also regenerates them following a heart attack, or myocardial infarction, as it is defined in medical terms. .

Published in Journal of Cardiovascular Aging (found here), this groundbreaking discovery has the potential to become a powerful clinical strategy for the treatment of heart disease in humans, at least according to Robert J. Shwartz, a distinguished professor at the University of Houston and author of the research.

How does this new technology work?

The new technology developed by the team of researchers uses a synthetic messenger ribonucleic acid (mRNA). The target? Carrying mutated transcription factors in mouse hearts, i.e. proteins that control the conversion of DNA to RNA.

In practice, this system allows the cells of the mouse heart tissue to produce molecules (proteins) that normally would not be able to produce, but which can induce tissue repair and / or regeneration.

The article continues after the related links

Absorbable organic electrodes: electrotherapy without surgery is a reality

The heart is polluted: the last place we found Microplastics

"Nobody has been able to do it this far. We think it could become a possible treatment for humans," said Schwartz, who led the study alongside Ph.D. Siyu Xiao and Dinakar Iyer, assistant professor of biology and biochemistry.

Repairing the heart muscle, the benefits

This type of technology has been studied extensively in recent years. The stamina cells and their use for the treatment of diseases linked to degeneration and aging are, in fact, protagonists in today's medical and biotechnological research. The aim is to return the cells of a tissue, therefore already well differentiated, to a state in which their fate can still be partially determined. This allows the cells to proliferate again, and then in any case differentiate again later and return to form the original tissue.

cardiac muscle cardiomyocytes
Histological section of cardiomyocytes: the muscle cells responsible for the functioning of the heart. Their aging is the cause of almost all heart malfunctions and even serious diseases.

"We are trying to 'undifferentiate' cardiomyocytes into a state more like stem cells, so that they can regenerate and proliferate," Xiao said.

In separate research, published in the same journal, the team will report that inoculated transcription factors repaired damaged mouse hearts in vivo. In particular, myocyte nuclei replicated at least 15 times in the 24 hours following the injection of these transcription factors into the heart muscle. A really interesting and promising result!

Good hopes

An added benefit of using synthetic mRNA, according to Xiao, is that it disappears in a few days compared to viral administration, which constitutes an alternative possibility for this type of procedure. Gene therapies administered to cells via viral vectors raise several biosecurity problems because they cannot be easily stopped. The administration of mRNA, on the other hand, causes it to degrade quickly and disappear.

We will see if this type of procedure can also become a reality for humans. Surely regenerative medicine is one of the most interesting and to keep an eye on among the modern sciences.

Source: Siyu Xiao, Rui Liang, Azeez B. Muili, Xuanye Cao, Stephen Navran, Robert J. Schwartz, Dinakar Iyer. Mutant SRF and YAP synthetic modified mRNAs drive cardiomyocyte nuclear replication. The Journal of Cardiovascular Aging, 2022; 2 (3): 29 DOI: 10.20517 / jca.2022.17

Tags: Heartcycle

Latest news

  • Without a brake from the institutions, will AI lead to private neo-feudalism?
  • When will we become extinct? Here comes a (nice) prediction from the supercomputer
  • DNA and longevity: how 'jumping genes' could extend our lives
  • TeddyGPT arrives, the first AI teddy bear that talks and learns with children
  • Minimum wage: a step forward or a leap in the dark for Italy?
  • Solar cars could halve the need for charging
  • The crazy food of the future: from edible clouds to mussel ceramics
  • NASA, recovered the sample from the asteroid Bennu: why it is important
  • Tesla and the new abilities of Optimus robots: "Ready for mass production"
  • EV, goodbye frequent charging: I-State promises over 1.000 km of autonomy.


GPT Chat Megaeasy!

Concrete guide for those approaching this artificial intelligence tool, also designed for the school world: many examples of applications, usage indications and ready-to-use instructions for training and interrogating Chat GPT.

To submit articles, disclose the results of a research or scientific discoveries write to the editorial staff

Enter the Telegram channel of Futuroprossimo, click here. Or follow us on Instagram, Facebook, Twitter, Mastodon e LinkedIn.

FacebookTwitterInstagramTelegramLinkedInMastodonPinterestTikTok

The daily tomorrow.


Futuroprossimo.it provides news on the future of technology, science and innovation: if there is something that is about to arrive, here it has already arrived. FuturoProssimo is part of the network ForwardTo, studies and skills for future scenarios.

  • Environment
  • Architecture
  • Artificial intelligence
  • Gadgets
  • concepts
  • Design
  • Medicine
  • Spazio
  • Robotica
  • Work
  • Transports
  • Energy
  • Edition Francaise
  • Deutsche Ausgabe
  • Japanese version
  • English Edition
  • Portuguese Edition
  • Read more
  • Spanish edition

Subscribe to our newsletter

  • The Editor
  • Advertising on FP
  • Privacy Policy

© 2023 Near future - Creative Commons License
This work is distributed under license Creative Commons Attribution 4.0 International.

No Result
View All Result
Understand, anticipate, improve the future.
  • Home
  • Tech
  • Health
  • Environment
  • Energy
  • Transports
  • Spazio
  • AI
  • concepts
  • H+