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Medicine

Urolithin A is shown to be effective against muscular dystrophy

The natural compound Urolithin A achieves excellent results in Duchenne muscular dystrophy in mice. We await those of human tests.

April 8 2021
Gianluca RiccioGianluca Riccio
⚪ 3 minutes
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Muscular dystrophy

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The progression of Duchenne muscular dystrophy (DMD) can be delayed in mice by supplementing their diet with urolithin A, according to new results reported today. The results, published on Science Translational Medicine, give hope that one day new treatment options may be developed for muscular dystrophy, a non-curable genetic condition characterized by progressive muscle degeneration. About 1 in 3.500 children are born with DMD, which significantly reduces life expectancy.

The new research is led by Professor Johan Auwerx, MD, PhD from the Swiss Federal Institute of Technology EPFL, and from the University of Lausanne in collaboration with scientists from the Swiss company Amazentis. He highlights the important role that defective mitochondria can play in muscular dystrophy. The power plants of cells, the mitochondria, produce the energy needed for normal muscle function. But muscle cells taken from human DMD patients and from mice under equivalent conditions show significant defects in mitochondrial activity. 

the role of mitophagy

In particular, gene expression models show that the development of Duchenne muscular dystrophy is associated with a marked decrease in mitophagy. Mitophagy is the process that cells rely on to remove and recycle defective mitochondria and keep energy levels high.

Duchenne muscular dystrophy is the most common fatal genetic disease diagnosed in childhood and a cure is not yet available. Our work represents a significant breakthrough in the search for new therapeutic approaches for muscular dystrophies.

Johan Auwerx, MD, PhD, lead author and professor at the EPFL.
Muscular dystrophy
an extract of the data from the research

Urolithin A and Duchenne muscular dystrophy

The natural compound urolithin A is known to activate mitophagy and improve mitochondrial health in both mice and humans. When the study scientists and lead authors, Peiling Luan e Davide D'Amico, they fed the compound to mice with Duchenne muscular dystrophy for just ten weeks. Levels of mitophagy effectively increased to bring them back to normal, with a significant reduction in muscle damage. THE mice with DMD given urolithin A, they saw a 45% increase in running performance compared to untreated control animals. And they lived longer: on average 40% more.

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Importantly, for human disease, urolithin A reduced a harmful condition called fibrosis in the muscles of the heart and diaphragm by 36% and 39%, respectively. Similar damage seen in patients with Duchenne muscular dystrophy typically leads to fatal heart or respiratory failure. Urolithin A was also able to enhance the regeneration of mouse muscle stem cells. This is particularly relevant for human disease as the onset of DMD is linked to the depletion of functional stem cells.

Prior to this study, it was understood that dramatic loss of muscle function in patients with Duchenne muscular dystrophy was associated with mitochondrial dysfunction. Here we found that defective mitophagy, the removal and recycling of dysfunctional mitochondria, play a key role in the progression of DMD.

Davide D'Amico, PhD, Project Leader at Amazentis and first author of the article
Tags: Muscular dystrophymuscles

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