Near future
Contact us
  • Home
  • Tech
  • Health
  • Environment
  • Architecture
  • energia
  • Transportation
  • Spazio
  • AI
  • concepts
  • Gadgets
  • Italy Next
  • H+
July 1 2022

Coronavirus / Russia-Ukraine

Near future

News to understand, anticipate, improve the future.

No Result
View All Result

News to understand, anticipate, improve the future.

Read in:  Chinese (Simplified)EnglishFrenchGermanItalianJapanesePortugueseRussianSpanish

Experimental CRISPR therapy cuts cholesterol in mice by 57%

An extraordinary result of experimental therapies on mice shows how it is possible to reduce high cholesterol by 57% with a single injection. If it works on humans it will be a revolution.

Gianluca Ricciodi Gianluca Riccio
in Medicine
Share16Pin5Tweet10SendShare3ShareShare2
High cholesterol
March 8 2021
⚪ Reads in 3 minutes
A A

Scientists have improved a form of gene-editing therapy, creating an experimental treatment that promises to eliminate high cholesterol. A condition that affects hundreds of millions of people around the world, and linked to a number of serious health complications.

In new research conducted with mice, the researchers injected a newly formulated lipid nanoparticle to modify with CRISPR-Cas9 the genome of living animals. With a single treatment they reduced low-density lipoprotein (LDL) cholesterol levels al 56,8%.

High cholesterol
Cholesterol and triglycerides

To give you an idea: at the moment, the most advanced FDA approved treatment may (not yet on the market) reduce cholesterol by only 15,7%.

Maybe you are also interested

CRISPR can alter the social behavior of animals

Scientists are using CRISPR to create hypoallergenic cats

CINDELA, created a cancer treatment with no side effects

10 "miraculous" medical technologies to keep an eye on

Of course, these results have only been shown in mice so far, so the new therapy will require a lot of further testing before we know it's both safe and equally effective in humans. But based on these findings so far, the signs are promising.

How the revolutionary anti-cholesterol treatment works

The treatment acts on a gene called Angiopoietin-like 3 (Angptl3), and produces proteins that inhibit the breakdown of some fats in the bloodstream.

People with a mutation in this gene tend to have lower amounts of fatty triglycerides and cholesterol in their blood (with no health complications), and for years scientists have been trying to recreate the process, with treatments that effectively mimic the effects of this mutation.

"If we can replicate this condition by eliminating the Angptl3 gene in people, we have a good chance of having a safe, long-term solution to high cholesterol," says the biomedical engineer. Qiaobing Xu of Tufts University.

CRISPR against high cholesterol
Qiaobing Xu

Progress achieved

In this research, Xu's team developed a new formulation of LNP called 306-O12B to target the gene, producing therapeutic effects in mice that lasted at stable levels for 100 days after a single injection of the treatment.

In addition to lowering cholesterol, the experiment also produced one 29,4% decrease in blood triglycerides some animals.

The extraordinary action actually helps the body break down fats before they accumulate in the bloodstream. And with no apparent liver toxicity.

CRISPR anti-cholesterol: will it also work on humans?

The team suggests that the efficiency of high cholesterol treatment in humans would likely be roughly the same as that in mice. With effects that could last up to a year with a single injection, given the slow turnover of liver cells.

Until we know more about how 306-O12B acting in the human body, however, this cholesterol-lowering drug formulation will not be available in your local pharmacy.

But one day it will be possible. The results of this test can advance the CRISPR method in this area as well. More detailed studies are still needed on chronic tolerability and efficacy on large "animals", but sooner or later one injection per year could really eradicate cholesterol problems. Would be great.

The results are reported on PNAS.

tags: cholesterolCRISPR
Previous post

The expert: a future implant will cause an orgasm on command

Next Post

New study reveals: quantum mechanics causes mutations in DNA

COLLABORATE

To submit articles, disclose the results of a research or scientific discoveries write to the editorial staff

    archive

    Have a look here:

    POST FP 700X500 2022 04 22T113414.306
    Environment

    Earth Day: 5 killers of the planet and the solutions to stop them

    Let's take a look at the 5 biggest killers on our planet and what we can do to stop them.

    Read More
    New floating tunnels in Norway

    New floating tunnels in Norway

    exoskeletons

    Harvard studies exoskeletons that use ultrasound to adapt to the user

    Printed solar panels debut: only $ 10 per square meter

    Printed solar panels debut: only $ 10 per square meter

    Geothermal energy

    Geothermal energy is at a great crossroads

    The daily tomorrow

    Futuroprossimo.it provides news on the future of technology, science and innovation: if there is something that is about to arrive, here it has already arrived. FuturoProssimo is part of the network ForwardTo, studies and skills for future scenarios.

    Subscribe to our newsletter

    Environment
    Architecture
    Artificial intelligence
    Gadgets
    concepts
    Design

    Staff
    Archives
    Advertising
    Privacy Policy

    Medicine
    Spazio
    Robotica
    Work
    Transportation
    energia

    To contact the FuturoProssimo editorial team, write to [email protected]

    Chinese Version
    Édition Française
    Deutsche Ausgabe
    Japanese version
    English Edition
    Edição Portuguesa
    Русское издание
    Spanish edition

    This work is distributed under license Creative Commons Attribution 4.0 International.
    © 2021 Futuroprossimo

    No Result
    View All Result
    • Home
    • Tech
    • Health
    • Environment
    • Architecture
    • energia
    • Transportation
    • Spazio
    • AI
    • concepts
    • Gadgets
    • Italy Next
    • H+