She ran around the world to identify an effective coronavirus vaccine (here the latest developments). The next challenge will be to produce it and distribute it quickly worldwide.
A research team led by Maria CroyleProfessor of Pharmaceuticals at the University of Texas has developed a new method for stabilizing live viruses and other biological medicines. The vaccines are incorporated into a rapidly dissolving transparent film, a sort of "candy" that does not require refrigeration and can be administered orally.
The ingredients for making the vaccine film (a transparent disk resembling a host) are cheap and the process is relatively simple, it could make vaccination campaigns much faster. Large quantities of the device can be shipped and distributed easily given its "space-saving" form.
This new technology recently published in the journal Science Advances, has the potential to dramatically improve global access to vaccines and other biological medicines.
Inspired by candy
Dr. Croyle's team began developing this technology in 2007, when the National Institutes of Health asked to develop a stable, needle-free method of administration for a vaccine.
The idea of developing a film was inspired by a documentary on how the DNA of insects and other living things can be preserved in amber for millions of years.
It was a simple idea, but no one had tried it. The researchers began to work by mixing a variety of formulations containing natural ingredients such as sugars and salts and testing them for their ability to form a kind of flat "candy for vaccines".
Initially, many of the tested preparations killed the body as the film formed or crystallized, destroying the virus or bacteria that were to form the basis for a vaccine.
As many as 450 attempts later, the team found a formulation that could suspend viruses and bacteria in a transparent film to be dissolved in the mouth.
Oral vaccine on transparent film
The researchers' subsequent work simplified the process to the point that in-depth technical training would not be required to carry it out. Dosages and ingredients allow rapid distribution: a few hours from production to dispatch.
The advantages of this system
All stored vaccines lose their potency over time. The speed at which they do this depends mainly on the temperature at which they are maintained. Keeping vaccines continuously refrigerated is difficult and expensive - and in some parts of the world, almost impossible.
This is why creating vaccines on film, which can be stored and transported at room temperature is a huge advantage.
The development of the new type of distribution is also the result of a fortuitous discovery. Working on an Ebola vaccine, Maria Croyle's team studied films containing the virus over three years old. They rehydrated them for study purposes and found that over 95% of the viruses in the film were still active. Obtaining this type of shelf life for an unrefrigerated vaccine has been surprising.
The ecological footprint left by global immunization campaigns is never considered. The 2004 Philippine Measles Elimination Campaign immunized 18 million babies in one month. The "collateral" effect on the ecological level? 19,5 million syringes, 143 tons of sharp waste and nearly 80 tons of non-hazardous waste. Empty vials, syringe wrappers, caps, cotton buds and packaging. The implications for a broader campaign would be even more significant.
By contrast, Croyle's technology can be distributed by healthcare professionals with only one sachet. Once taken, this vaccine candy will leave no trace except (hopefully) for a healthy global population.