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Covid-19 Updates »

March 31 2020
in Medicine

"Me, coronavirus vaccine volunteer." The reason for the choice

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"Me, coronavirus vaccine volunteer." The reason for the choice
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Gianluca Ricciodi Gianluca Riccio
6 minutes of reading
tags: Coronavirusvaccines

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To stop the coronavirus you need a vaccine and volunteers willing to receive it to test it. The MIT magazine interviewed one. Here is his story.

Numerous vaccines are in development, but the first to be tested on the volunteer is a new type of coronavirus vaccine developed by Moderna Therapeutics. A company whose technology has enabled what is called "the fastest start of a vaccine study ever."

The first phase, ongoing now, is a safety trial to make sure the vaccine is not dangerous and that it provokes an effective immune response. In March, 45 people were asked to volunteer at a facility in Seattle.

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The 20-page consent form that volunteers are signing (you can download and read it in the box below), recognizes that there may be risks.

Consent form for testing the candidate for a coronavirus vaccineDownload

Volunteers also agree to undergo a series of blood samples in the coming months to share their genetic information. And they agree to give up having children during the study period.

Il MIT Technology Review Magazine interviewed Ian Haydon, a communications specialist at the University of Washington. Ian explained why he decided to volunteer for the coronavirus vaccine and how he was chosen. The following is the translation of the interview.

You will be among the first 45 people to receive a coronavirus vaccine. Why did you decide to do it?

Good question! I'm a public information specialist at the University of Washington, specifically for the Institute for Protein Design, which is doing research on covid-19. There are 35 people in the lab working on the vaccine. The rest stays at home. I have never been the subject of one of these studies, but I live them closely and the idea of ​​being able to participate in a different way seemed to me the right thing to do.

When will you receive the vaccine?

April 8 at nine in the morning. And a second dose about a month later.

How were you chosen for this study?

Luck, above all. I heard about the study from a lab colleague who told me about the recruitment. I submitted my health information - they wanted to know my health and age history. I didn't expect to hear from them, because they had thousands of answers. But they chose me. I went for a physical and blood exam, and they explained the study to me. They asked me if I was still interested in volunteering for this coronavirus vaccine. I said yes and signed up.

Any fears?

No. I was looking forward to the call.

How old are you?

I'm 29.

Did you tell your parents? What do they think?

My parents had it while I was on my way to do the first physical exam. I also told my girlfriend at that moment. I think my parents are proud: my mother is a little worried, understandably.

What do you think the risks are?

I think there are some small risks. The first is anaphylactic shock, which can be a problem for a small number of people and is not a unique risk in this study. Another small risk, and it is not clear whether it is relevant to covid-19, is called "antibody-dependent enhancement" (when a vaccine worsens a disease).

This is part of what they are evaluating, I suppose. The third level of risk is the unexpected. This exists for any vaccine, especially those based on new technologies.

How does the vaccine work?

This is an mRNA vaccine. Part of the virus's genetic code is found in the vaccine, in a lipid nanoparticle, which is essentially a ball of fat. When injected into a volunteer like me, it is supposed to make the protein, in this case the coronavirus peak protein. This is what is supposed to make my immune system react and produce antibodies. The vaccine delivers the genetic material directly and not the proteins.

How long should you develop antibodies?

This will be monitored throughout the trial period, for more than one year. Each visit will check my antibodies and immune cells.

You did some research on technology?

Yes a little bit. My understanding is that this vaccine platform for lipid nanoparticles has passed some phase 1 studies for infections other than coronavirus. In fact, what the clinicians said was that one in three patients who received an mRNA vaccine had severe pain that interfered with normal activity for the rest of the day.

What is your opinion on Moderna?

I think their technology is amazing and I'm glad it's being tested. It could be an important platform not just for the coronavirus but for many diseases. Their decision to develop a coronavirus vaccine and test it in humans in the midst of a pandemic is an extraordinary thing for any company. They are putting everything into play, I hope it works.

Do you receive a refund for your contribution?

I think it's $ 100 per visit, so about $ 1.000 in all.

The new coronavirus Did Covid-19 hit you personally?

I think like almost everyone else, this pandemic has disrupted my life. Working from home, being quarantined and most importantly being a resident of Seattle. The whole experience has broken down some of the walls between my personal and professional life.

Many people are experiencing it. I know that many scientists at the university have volunteered to process clinical samples that arrive in the laboratory. This is not their daily job. People have moved their jobs. I haven't been close to the infection itself, but I feel it around me.

The evidence paper states that the safety study lasts 14 months. Why so long? Don't we need an answer first?

I've heard they may have a clear safety indication by the third month. If the safety data is clear by the third month and the coronavirus continues to be the problem, I expect phase 2 studies to start soon. But these clinical trials cannot be accelerated that much. This is already the fastest vaccine candidate that has ever entered humans.

Do you think there is a chance that the vaccine will protect you?

I suppose it is possible. But part of what they're doing with the vaccine is evaluating different doses, so I'm not going to take it for granted that they're getting immunity from the coronacirus.

The consent form makes it clear enough that everyone involved in the process should avoid new births. What is it about?

I wonder too. I have theories. I was specifically asked to use contraceptives. I wonder if, being a genetic vaccine, anyone wanted to avoid the birth of a new generation of children vaccinated with mRNA.

Do you mean that DNA could end up in the germ line, in your sperm?

I guess the scientists themselves think it's a possibility they don't want to explore. Whether or not there is a molecular mechanism that would make it possible, it seems responsible not to continue down that path.

How is it to know that you will contribute so directly?

I feel lucky to be able to volunteer to fight the coronavirus. I am lucky to be healthy enough to participate. I am lucky to have been selected from a large pool, and I hope that many people in my position can participate as well.

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The author

Gianluca Riccio, copywriter and journalist - Born in 1975, he is the creative director of an advertising agency, he is affiliated with the Italian Institute for the Future, World Future Society and H +, Network of Italian Transhumanists.

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