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May 27, 2022

Coronavirus / Russia-Ukraine

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Coronavirus vaccine: in 2003 in 20 months, today in 3 months

The situation in Wuhan worsens, but the scientific reaction is powerful: in 2003 it took 20 months to test a coronavirus vaccine. Today 3 will be enough.

Gianluca Ricciodi Gianluca Riccio
in Medicine
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January 27 2020
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Le latest from Wuhan they shiver, but there is also good news. In 2003 it took 20 months to find the first experimental treatment against the newly identified virus: in 2020 it will take 3 months for the first treatments against Wuhan's Coronavirus.

China has already published the genome sequence of the Wuhan Coronavirus and experimental vaccines are expected to be tested in humans by April 2020 for a coronavirus vaccine in record time.

In other words, within the next 90 days, a number of potential experimental vaccines will already be available for use against the new coronavirus that is spreading in China and beyond.

It is the fastest timeline in which the NIH agency's National Institute of Allergy and Infectious Diseases has ever developed for a vaccine against a new disease.

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Chinese scientists have identified the genetic sequence of the novel coronavirus with astonishing speed, and officials have made it public within days. On January 24, 2020, the US CDC published the entire genome of the 2019-nCoV virus detected in the first US patient in Seattle, Washington on GenBank.

CDC developed a real-time reverse polymerase chain reaction test (rRT-PCR). It is able to diagnose 2019-nCoV in respiratory and serum samples from clinical samples.

Coronavirus, in 2003 it took much longer for a vaccine

In the 2003 outbreak of severe acute respiratory syndrome (SARS), it took US scientists a whopping 20 months to transition from the genetic sequence to the first phase of human trials.

The 2019-nCoV infection caused clusters of severe respiratory diseases, with admission to intensive care and high mortality.

Rapid treatment and mRNA

US biotechnology company Moderna Inc specializes in ribonucleic acid (RNA) -based vaccines. A chemical messenger that contains instructions for making proteins. Moderna is collaborating with the NIH on the development of the new coronavirus vaccine (2019-nCoV).

The aces in the sleeve of Moderna? A remarkable technological platform. Moderna has created an mRNA technology platform that works much like an operating system on a computer. It is designed in such a way that it can be connected and played interchangeably with different programs. In our case, the "program" or "app" is our drug mRNA - the unique mRNA sequence that codes for a protein.

In practice, the system can operate more "attempts" on a vaccine, can do it in a short time and motivate everything.

If you combine the fully integrated production site and development experience, you understand how these skills are fundamental.

Skills that allowed Moderna to quickly identify and progress a vaccine candidate.

Let's hold on: if everything goes as it should, it will be an Easter of true resurrection.

tags: CoronavirustherapiesWuhan
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