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October 14, 2019
in Medicine

Regenerating the cartilage, here is the key factor: man also has it

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Regenerating the cartilage, here is the key factor: man also has it
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tags: ArtiRegenerative medicineRNA

Regenerate the cartilages of the joints, perhaps entire limbs, a like salamanders? The key factors of this ability have been discovered: man also possesses them.

Gianluca Ricciodi Gianluca Riccio
3 minutes of reading

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“We believe that we must continue on the path of understanding this newly discovered regenerative capacity in humans. The identification of the key components of this circuit will give us new approaches to repair and regeneration of joints, and perhaps of entire limbs ”.

That's what he says Virginia Byers Kraus. Professor in the Department of Medicine, Pathology and Orthopedic Surgery at Duke University. The statement is part of the commentary on your search results on the human possibility of regenerating cartilages, and perhaps entire limbs.

To accomplish this, Kraus and colleagues (including the first signature of the research, PhD Ming-Feng Hsueh) had to find a way to determine the age of proteins in the body.

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Through spectrometry, the team verified which pivotal proteins in human cartilages were young, 'adult' or old.

The more you go up, the more you go down

A curious finding is that the age of the cartilage is higher as it rises in the body. The cartilage in the ankles is young, the cartilage in the knees is middle-aged, and the cartilage in the hips is old.

They deduced that the age of the cartilages is related to the repair mechanisms that some animals such as the salamander have, capable of regenerating even entire extremities such as legs or tail.

The role of the MicroRNA

The team also found that protein molecules called microRNAs are responsible for regulating these processes in animals. And we also have microRNA, in our body it helps to repair damaged tissues: therefore there is the potential to regenerate cartilage as well.

"We are thrilled that the regulators of limb regeneration in animals are the same ones that control repair in human tissues," says Hsueh. "Let's say that man has a 'salamander' joint ability that has not yet expressed its potential".

Not just knees: the regeneration capacity of cartilage would also be useful for the femur, ankles and in general all the parts affected by arthritis
Shoulders too.

The consequences of the research

The team now believes microRNA could become the basis for a whole new generation of arthritis drugs that can rebuild damaged cartilage.

"We believe we can boost these regulators, even at the cellular level, to make sure that the cartilages of an arthritic joint completely regenerate. If we can add the missing 'ingredients' and understand at what point in the process we stop, it will be possible to reconstruct parts of a limb, or perhaps whole limbs. And the mechanism can be applied to different tissues, not just cartilages ".

The study was published in the journal Science Advances.

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The author

Gianluca Riccio, copywriter and journalist - Born in 1975, he is the creative director of an advertising agency, he is affiliated with the Italian Institute for the Future, World Future Society and H +, Network of Italian Transhumanists.

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