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Medicine

A human liver created from scratch after 5 years of trying

The importance of creating a human liver from a skin sample? Huge: it will be possible to create mini-organs to test human cures without risk.

October 13, 2019
Gianluca RiccioGianluca Riccio
⚪ 2 minutes
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In a hospital container today there is a human liver. It was not explanted by anyone, it was created. And it took quite a while.

"In fact it wasn't like waking up and having a human liver from scratch overnight," says Alejandro Soto-Gutierrez of the Liver Research Center in Pittsburgh.

It took 5 years of failures and attempts to succeed: using genetic and tissue engineering, organ and stem cell cultures, a team of experts in the various areas contributed to the result that the researchers achieved.

How did they create a human liver from scratch?

Alexandra Collin area of University of Pittsburgh School of Medicine explains the process:

  1. A rat liver is deprived of all its cells to obtain only the connective tissue.
  2. From a sample of human skin, scientists pull out stem cells and turn them into human liver cells, starting to grow them.
  3. Once cultured, the cells are injected into a special "bioreactor" which helps to position them in the "empty" rat liver.

The whole process, from harvesting and growing the cells to the last stage (a mini-liver in a bioreactor) takes several months. Once obtained, the liver remains "alive" only a few days.

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Human liver

Very important for research

In this short period of time, researchers can test different drugs, having practically a human organ available without the need to have volunteers for tests, or animal guinea pigs. It is a very important step forward in the research and development of new drugs.

With this system it is already possible to create a liver with certain diseases, ready to be "healed" by laboratory tests specially organized.

In the future, the potential will all shift to personalized medicine: before starting a therapy, you can take a sample of our tissues and create a mini-replica of our liver to safely perform all the tests and see which therapy responds best.

For the transplants instead we have to wait a few years, but also in that field the progress thanks to these developments will be considerable.

Tags: bioreactorstamina cellsLivertransplants


GPT Chat Megaeasy!

Concrete guide for those approaching this artificial intelligence tool, also designed for the school world: many examples of applications, usage indications and ready-to-use instructions for training and interrogating Chat GPT.

To submit articles, disclose the results of a research or scientific discoveries write to the editorial staff

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