Celiac disease is a chronic autoimmune disorder. It can have serious long-term consequences for people who continue to ingest gluten.
Being a very elusive condition, it takes an average of four years to receive a correct diagnosis. Not only that, but testing for celiac disease can get a little too invasive.
With the incidence of celiac disease steadily growing, a simple blood test is desperately important. This is why several world-class experts are working on it.
Conducting a dozen clinical trials in Australia, New Zealand and the USA, the team discovered a marker in the blood of almost all celiacs. An inflammatory response that appears within a few hours of eating gluten.
The results are so promising that researchers are already considering the possibility of spreading an easier and faster diagnostic test.
“For most people consuming gluten-free foods without a specific diagnosis of celiac disease, all that would be needed is a blood test before and one 4 hours after ingesting gluten. “ To say it is Jason Tye Din, gastroenterologist and researcher at Royal Melbourne Hospital.
“It would be a revolution compared to the current approach that requires people to eat gluten for several weeks before carrying out a biopsy, an invasive test of the intestine.”
A long and uncomfortable process. In some cases, fortunately not many, due to the timing so dilated it also has little reliability in the results.
Two small samples, one gluten intake and above all no interventions on the body would definitely change the situation for the better.
The research
Tye-Din and colleagues gave volunteers an injection under the skin of gluten peptides, or a flour-based solution in various dosages. From the reactions the evaluation: some elements in the body called cytokines increase already two hours after intake.
When the volunteers received a double dose of gluten, their symptoms increased accordingly (nausea and vomiting). With them also the level of cytokines.
“The unpleasant symptoms associated with this disorder are linked to an increase in inflammatory molecules in the blood, such as interleukin 2, also produced by the immune system,” says Robert Anderson, scientific leader of the research.
“It is a response similar to those that occur when there is an infection in the body. The difference is that for a celiac the triggering factor is gluten."
Several members of the research work at ImmusanT. The company is developing a 'vaccine' based on peptides, which will function as an immunizing therapy for celiacs.
It seems that we are finally there. A short distance between them we may find ourselves a new diagnostic test and a vaccine.
